Next-Gen Intelligent TechBio

We enable patient-derived epithelial organoids for high-throughput, multi-modal genetics-proteomics-histology phenotypic profiling, revolutionizing biopharma  and medicare with unleased AI.

Alvus Partnered with
NASA+MGH+SpaceTango
to send PDO  to SPACE
In March 2024
NASA sent our organoids to space

Next-Gen Intelligent TechBio

We enable patient-derived epithelial organoids for high-throughput, multi-modal phenotypic profiling, revolutionizing biopharmaceutical discovery with unleased AI.

Alvus+ NASA+MGH
sent PDO  to space
Alvus Partnered with NASA+MGH+SpaceTango
to send PDO  to SPACE in March 2024
Alvus  is trusted and working with incredible teams:
Harvard Innovation labs logoMass General logoDartmouth General School of Medicine logoVirgina Tech logoUniversity of Rochester logoRIT logo

A Surrogate Human Epithelial Organ System

Capitalizing on the breakthrough with GI epithelial organoids, Alvus is diversifying its surrogate organ biobank, preserving the molecular, structural, and functional characteristics of their origins. We leverage our insights into biophysical properties and disease mechanisms across various human epithelial tissues.

Intestinal
Lung
Stomach
Cerebral
Urinary
Ovarian

We can collect various human organoids

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Intestinal
Lung
Stomach
Cerebral
Urinary
Ovarian

Enables new era of rapid, low-cost high throughput screening and identification

Alvus's organoids merge the benefits of cell lines and 3D organoids.

Cell Line

3D Organoid

Alvus Health

Physiology

Low

High

High

Throughput

High

Low

High

Cost efficiency

High

Low

High

Standarization

High

Low

High

Enables new era of rapid, low-cost high throughput screening

Our organoid culturingtakes 1 week and 20% cost. Our model combines the advantages of both cell line and 3D organoids.

Physiological relevance

Throughput capacity

Cost efficiency

Cell line

2D

Low

Disadvantages:
  • No any info in organ level

High

High

Organoinds

3D

Medium

Disadvantages:
  • Loss of open-lumen anatomy
  • Artifical pressure
  • Short term culture
  • Dead cell accumulation

Low

Disadvantages:
  • Long time commitment
  • Custom-made media
  • High cost of Matrigel

Low

Disadvantages:
  • Heterogeneity
  • Tedious protocol
  • Difficult imaging process
  • Variation in Matrigel

Alvus Health

2.5D

High

High

Medium

Enables new era of rapid, low-cost high throughput screening

Our organoid culturingtakes 1 week and 20% cost. Our model combines the advantages of both cell line and 3D organoids.

Physiological relevance

Cell line

2D

Low

Disadvantages:
  • No any info in organ level

Organoinds

3D

Medium

Disadvantages:
  • Loss of open-lumen anatomy
  • Artifical pressure
  • Short term culture
  • Dead cell accumulation

Alvus Health

2.5D

High

Throughput capacity

Cost efficiency

High

High

Low

Disadvantages:
  • Long time commitment
  • Custom-made media
  • High cost of Matrigel

Low

Disadvantages:
  • Heterogeneity
  • Tedious protocol
  • Difficult imaging process
  • Variation in Matrigel

High

Medium

Cell line

2D

Organoinds

3D

Alvus Health

2.5D

Physiological relevance

Low

Disadvantages:
  • No any info in organ level

Medium

Disadvantages:
  • Loss of open-lumen anatomy
  • Artifical pressure
  • Short term culture
  • Dead cell accumulation

High

Throughput capacity

High

Low

Disadvantages:
  • Long time commitment
  • Custom-made media
  • High cost of Matrigel

High

Cost efficiency

High

Low

Disadvantages:
  • Heterogeneity
  • Tedious protocol
  • Difficult imaging process
  • Variation in Matrigel

Medium

Automation and Screening

Alvus's organoids easily integrate with high-throughput automation, facilitate cell transfection for gene editing, and streamline imaging data collection.

01
02
03
04
Organoids cultureOrganoids cultureOrganoids cultureOrganoids culture
01
02
03
04
Organoids cultureOrganoids cultureOrganoids cultureOrganoids culture

Automation and Screening

Alvus's organoids easily integrate with high-throughput automation, facilitate cell transfection for gene editing, and streamline imaging data collection.

01
02
03
04
Organoids cultureOrganoids cultureOrganoids cultureOrganoids culture
01
02
03
04
Organoids cultureOrganoids cultureOrganoids cultureOrganoids culture

Automation and Screening

Alvus's organoids easily integrate with high-throughput automation, facilitate cell transfection for gene editing, and streamline imaging data collection.

01
02
03
04
Organoids cultureOrganoids cultureOrganoids cultureOrganoids culture
01
02
03
04
Organoids cultureOrganoids cultureOrganoids cultureOrganoids culture

High-throughput automated organoid culturing and AI-enabled phenotypic analysis  optimizes and amplifies intricate biological research

Collaborating with pioneering centers advancing lab automation, such as the Harvard ICCB-Longwood Screening Facility, Alvus harnesses high-throughput organoid screening to explore small molecules and functional genomics.

Healthy

Crypt-villus morphology
via nuclear staining

CRC

Crypt-villus morphology
via nuclear staining

Healthy

Permeability
via ZO-1

Healthy

Stem cells
via LGR5

Scalable Data:
All-round Phenotypic Profiling via Multiplex Staining and Sequencing

Phenotypic assays monitor the establishment of cell morphology and phenotype of interest in a target-agnostic manner, enabling the exploration of vast biological space. By leveraging advanced multiplex imaging techniques, we can profile the molecular characteristics of organoids at the single-cell level.

CRC

Permeability
via ZO-1

Healthy

Goblet cells 
via MUC-2

CRC

Enterocytes
via ALPI

Healthy

Enterocytes
via ALPI

CRC

Goblet cells 
via MUC-2

CRC

Stem cells
via LGR5

Healthy

Crypt-villus morphology
via nuclear staining

CRC

Crypt-villus morphology
via nuclear staining

Healthy

Permeability
via ZO-1 staining

CRC

Permeability
via ZO-1 staining

Healthy

Stem cells
via LGR5 staining

CRC

Crypt-villus morphology
via nuclear staining

Healthy

Crypt-villus morphology
via nuclear staining

Scalable Data:
All-round Phenotypic Profiling via Multiplex Staining and Sequencing

Phenotypic assays monitor the establishment of cell morphology and phenotype of interest in a target-agnostic manner, enabling the exploration of vast biological space. By leveraging advanced multiplex imaging techniques, we can profile the molecular characteristics of organoids at the single-cell level.

Healthy

Stem cells
via LGR5 staining

CRC

Permeability
via ZO-1 staining

Healthy

Crypt-villus morphology
via nuclear staining

CRC

Crypt-villus morphology
via nuclear staining

Healthy

Permeability
via ZO-1 staining

CRC

Permeability
via ZO-1 staining

Healthy

Stem cells
via LGR5 staining

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